Orexin/hypocretin is necessary for context-driven cocaine-seeking
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چکیده
منابع مشابه
Orexin/hypocretin is necessary for context-driven cocaine-seeking.
Orexin/hypocretin signaling at the orexin 1 receptor (OX(1)R) has recently been implicated in addiction and relapse. We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Male Sprague-Dawley rats self-administered cocaine in 2-h sessions for 10 days, followed by extinction t...
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Human and preclinical models of addiction demonstrate that gonadal hormones modulate acquisition of drug seeking. Little is known, however, about the effects of these hormones on extinction of drug-seeking behavior. Here, we investigated how 17β-estradiol (E₂) affects expression and extinction of cocaine seeking in female rats. Using a conditioned place preference (CPP) paradigm, ovariectomized...
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Lesion and neuroimaging studies suggest that the orbitofrontal cortex (OFC) supports temporal aspects of episodic memory. However, it is unclear whether OFC contributes to the encoding and/ or retrieval of temporal context and whether it is selective for temporal relative to non-temporal (spatial) context memory. We addressed this issue with two complimentary studies: functional magnetic resona...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2010
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2009.06.042